Adult Dosing
Intermittent claudication, symptomatic treatment
- 100 mg PO bid
- 50 mg PO bid if taking CYP3A4 inhibitors (like ketoconazole, itraconazole, erythromycin, diltiazem) or CYP2C19 inhibitors (omeprazole)
- Note: Give 30 mins before or 2 hrs after breakfast and dinner; beneficial effect may take up to 12 weeks
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
[Outline]
Renal Dose Adjustment (Based on CrCl)
- < 25 mL/min: Use with caution, dose adjustments not defined
Hepatic Dose Adjustment
- Mild hepatic impairment: No dose adjustments
- Moderate-severe hepatic impairment: Use with caution, dose adjustments not defined
- Cilastozol and its metabolites are inhibitors of phosphodiesterase III; risk of decreased survival compared to placebo in patients with CHF [U.S Black Box warnings]
- Rare cases of thrombocytopenia or leukopenia progressing to agranulocytosis have occurred, however, agranulocytosis was reversible on immediate discontinuation of cilostazol
- Limited information on safety and efficacy of concurrent use of cilostazol and clopidogrel; check bleeding times during coadministration
- Avoid grapefruit juice
- Monitor patient for signs and symptoms of bleeding, especially those concurrently on other anticoagulants
- Assess patient for adverse cardiac events and for signs of CHF
Cautions: Use cautiously in
- Severe renal impairment
- Moderate to severe hepatic impairment
- Cardiovascular disease
- Concomitant use of other antiplatelet agents
- Concomitant use of CYP3A4/CYP2C19 inhibitors (dose reduction recommended)
- Thrombocytopenia
- Risk of bleeding from surgery or pathological process
Pregnancy Category:C
Breastfeeding: Safety unknown. Use not recommended.
Pricing data from www.DrugStore.com in U.S.A.
- Cilostazol 50 MG TABS [Bottle] (TEVA PHARMACEUTICALS USA)
60 mg = $107.99
180 mg = $309.99 - Pletal 50 MG TABS [Bottle] (OTSUKA AMERICA)
60 mg = $132.99
180 mg = $366 - Cilostazol 100 MG TABS [Bottle] (ROXANE)
60 mg = $27.99
180 mg = $73.96 - Pletal 100 MG TABS [Bottle] (OTSUKA AMERICA)
60 mg = $114.98
180 mg = $330.96
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
