Adult Dosing
Prevention of nausea/vomiting associated with chemotherapy
- 1.8 mg/kg IV 30 min prior to chemotherapy given as a single dose
- Max: 100 mg/dose
Prevention of post-operative nausea/vomiting
- 12.5 mg IV 15 min before end of anesthesia
Treatment of post-operative nausea/vomiting
- 12.5 mg IV at the onset of nausea/vomiting
Pediatric Dosing
Prevention of nausea/vomiting associated with chemotherapy
- 2-16 yrs: 1.8 mg/kg IV 30 min prior to chemotherapy given as a single dose
- Max: 100 mg/dose
Prevention of post-operative nausea/vomiting
- 2-16 yrs: 0.35 mg/kg IV 15 min before end of anesthesia
- Max: 12.5 mg/dose
Treatment of post-operative nausea/vomiting
- 2-16 yrs: 0.35 mg/kg IV at the onset of nausea/vomiting
- Max: 12.5 mg/dose
[Outline]
- Therapy is associated with changes in ECG interval (PR, QTc, JT prolongation and QRS widening). Cardiovascular consequences, including heart block or cardiac arrhythmias have occurred on prolongation of intervals
- Possibility of cardiac conduction abnormality exists
- Rare occassions of sustained supraventricular and ventricular arrhythmias, cardiac arrest leading to death, and myocardial infarction has occurred in children and adolescents
- Possibility of development for cross hypersensitivity reactions in patients receiving other selective 5HT3 receptor antagonist exists
- Monitor K, Mg at baseline, then if essential after administration of this drug; Determine ECG and blood pressure if bradycardia, CHF
Cautions: Use cautiously in
- Renal impairment
- Cardiac conduction defects
- QT prolongation
- Congenital QT syndrome
- QT prolonging agent use
- Electrolyte disturbances
- Hypokalemia
- Hypomagnesemia
- Concomitant administration of diuretics
- Cumulative high-dose anthracycline therapy
- Concomitant administration of antiarrhythmic drugs or other drugs leading to QT prolongation
- Pediatrics having risk for developing prolongation of cardiac conduction intervals particularly QTc
Pregnancy Category:B
Breastfeeding: Safety unknown; manufacturer advises caution.
Pricing data from www.DrugStore.com in U.S.A.
- Anzemet 20 MG/ML SOLN [Vial] (SANOFI-AVENTIS U.S.)
5 ml = $49.99
15 ml = $135.96
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
