Adult Dosing
Ulcerative colitis, active mild to moderate
- Asacol, Asacol HD,Delzicol : 800 mg PO tid x 6 wks
- Lialda: 2.4-4.8 g PO qd. Max: 8 wks
- Pentasa: 1000 mg PO qid x 8 wks
Ulcerative coltis, maintenance therapy
- Apriso: 1.5 g PO qam
- Asacol: 800 mg PO bid
- Delzicol: 1.6 g/day PO in divided doses
Note:
- Take Delzicol 1 hour before or 2 hours after meal
Crohn's Disease [Non-FDA approved]
- Asacol, Asacol HD: 800 mg PO tid x 6 wks
- Lialda: 2.4-4.8 g PO qd. Max: 8 wks
- Pentasa: 1000 mg PO qid x 8 wks
Note:
Pediatric Dosing
- Safety and effectiveness in pediatric patients have not been established
Ulcerative colitis, active mild to moderate
Asacol
- 17 to <33 kg: 36-71 mg/kg/day divided bid x 6 wks. Max: 1.2 g/day
- 33 to <54 kg: 37-61 mg/kg/day divided bid x 6 wks. Max: 2.0 g/day
- 54 to 90 kg: 27-44 mg/kg/day divided bid x 6 wks. Max:2.4 g/day
Crohn's Disease [Non-FDA approved]
- 50 mg/kg/day PO divided q6-12 hrs
See Supplemental Patient Information
- Mesalamine is an active component of sulfasalazine. Patients experienced hypersensitivity to sulfasalazine may have a similar reaction to mesalamine. Caution should be exercised
- Mesalamine may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible patients
- Monitor renal function prior to starting therapy and periodically in patients with preexisting renal disease. Worsening of renal function may occur in patients with preexisting renal disease
- Reports of renal impairment, including minimal change nephropathy, and acute or chronic interstitial nephritis have been associated with mesalamine
- Some products may contain sulfites, which may cause allergic reactions in susceptible individuals
- Exacerbation of colitis characterized by cramping, acute abdominal pain, bloody diarrhea, fever, headache, malaise, pruritus, conjunctivitis, and rash may occur
- Rare cases of acute intolerance syndrome have been reported with therapy. Promptly discontinue treatment if acute intolerance syndrome is suspected
- Mesalamine may lead to elevated test results when measuring urinary normetanephrine by liquid chromatography with electrochemical detection. Consider alternative, selective assay for normetanephrine
Cautions: Use cautiously in
- Hepatic impairment
- Renal impairment
- Hx of sensitivity to sulfasalazine
- Pyloric stenosis (gastric retention may occur)
- Myocarditis risk
- Pericarditis risk
- Pregnancy
- Lactation (safety not established)
Supplemental Patient Information
- Advise patients to report any unexplained bleeding, bruising, purpura, sore throat, fever or malaise that occurs during treatment
Pregnancy Category:B
Breastfeeding: Poorly excreted in breastmilk. However the metabolite N-acetyl-5-ASA is excreted in high levels. Monitor the breastfed infant for diarrhea. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 28 May 2010).
Pricing data from www.DrugStore.com in U.S.A.
- Apriso 0.375 GM CP24 [Bottle] (SALIX PHARMACEUTICALS)
INC. gm = $120
gm = $360 - Lialda 1.2 GM TBEC [Bottle] (SHIRE US INC.)
120 gm = $766.97
360 gm = $2211.01 - Pentasa 250 MG CPCR [Bottle] (SHIRE US INC.)
240 mg = $332.01
720 mg = $952.94 - Pentasa 500 MG CPCR [Bottle] (SHIRE US INC.)
30 mg = $90.99
90 mg = $247.96 - Asacol HD 800 MG TBEC [Bottle] (WARNER CHILCOTT PROF PROD DIV)
90 mg = $390.01
180 mg = $760
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
