| Early signs | Late signs |
|---|
| Level of consciousness | - Requires increased stimulation
- Subtle orientation loss
- Restlessness and anxiety
- Sudden quietness
| |
| Pupils | - Pupil changes
- One pupil constricts but then dilates (unilateral hippus)
- Both pupils sluggish
- Unequal pupils
| - Pupils fixed and dilated or "blown"
|
| Motor response | - Sudden weakness
- Motor changes
- Positive pronator drift (with palms up, one hand pronates)
| |
| Vital signs | | - Increased systolic pressure, profound bradycardia, abnormal respirations
|