section name header

Pronunciation

fat ee-MUL-shun

Classifications

Therapeutic Classification: caloric sources

Indications

REMS

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: IV administration results in complete bioavailability.

Distribution: Distributes into intravascular space.

Metabolism/Excretion: Cleared by conversion to triglycerides, then to free fatty acids and glycerol by lipoprotein lipase. Free fatty acids are transported to tissues, where they may be oxidized as an energy source or re-stored as triglycerides.

Half-life: 30–60 min.

Time/Action Profile

ROUTEONSETPEAKDURATION
IVunknownunknownunknown

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Exercise Extreme Caution in:

Adv. Reactions/Side Effects

Seen only with long-term use.†

CV: chest pain.

Endo: hypertriglyceridemia.

GI: hepatomegaly†, jaundice†, nausea, pancreatitis, vomiting.

Local: phlebitis at IV site.

Resp: INTRAVASCULAR FAT ACCUMULATION(PRETERM INFANTS ONLY).
Misc: fever, infection, chills, hypersensitivity reactions.

Interactions

Drug-Drug:

Route/Dosage

see Calculator

Total Parenteral Nutrition

Essential Fatty Acid Deficiency

Availability

Assessment

Lab Test Considerations: Toxicity and Overdose:

Implementation

IV Administration:

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Intralipid, Liposyn III