REMS
Absorption: Well absorbed following oral administration.
Distribution: Crosses the blood-brain barrier and placenta.
Protein Binding: >90%.
Half-Life: 1036 hr (↑ in renal impairment).
Contraindicated in:
Use Cautiously in:
CV: edema, hypotension, tachycardia, HF, palpitations
Derm: hirsutism, rash
Endo: hyperglycemia, DIABETIC KETOACIDOSIS, HYPEROSMOLAR NONKETOTIC COMA, hyperuricemia
GI: abdominal pain, diarrhea, ILEUS, loss of taste, nausea, vomiting
GU: glycosuria
Hemat: neutropenia, thrombocytopenia
MS: weakness
Neuro: headache
Resp: PULMONARY HYPERTENSION
Drug-drug:
Drug-Natural Products:
Hyperinsulinemic Hypoglycemia
Lab Test Considerations:
Toxicity and Overdose: