REMS
Absorption: Rapidly absorbed; absorption delayed by high-fat meal by 2 hr.
Distribution: Moderate tissue distribution, does not cross the blood-brain barrier.
Protein Binding: 9394%.
Half-Life: 11 hr.
Contraindicated in:
Use Cautiously in:
GI: abdominal pain, diarrhea, gastroenteritis, GI PERFORATION, nausea, vomiting
Misc: opioid withdrawal
Drug-drug:
Drug-Natural Products: