section name header

Pronunciation

dye-klor-FEN-a-mide

Classifications

Therapeutic Classification: diuretics

Pharmacologic Classification: carbonic anhydrase inhibitors

Indications

REMS


Action

  • Inhibits renal carbonic anhydrase, resulting in self-limiting urinary excretion of sodium, potassium, bicarbonate, and water.
Therapeutic effects:
  • Reduced incidence/severity of muscle weakness associated with periodic paralysis.

Pharmacokinetics

Absorption: Well absorbed following oral administration.

Distribution: Crosses the placenta.

Metabolism/Excretion: Unknown.

Half-Life: Unknown.

Time/Action Profile

ROUTEONSETPEAKDURATION
POunknownunknownunknown





Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: pruritus, rash, STEVENS-JOHNSON SYNDROME

EENT: pharyngolaryngeal pain

F and E: hyperchloremic non-anion gap metabolic acidosis, hypokalemia

GI: diarrhea, nausea

Hemat: APLASTIC ANEMIA, HEMOLYTIC ANEMIA, LEUKOPENIA

Metab: weight

MS: arthralgia, muscle spasms/twitching

Neuro: confusion, drowsiness, dysgeusia, paresthesias, fatigue

Resp: dyspnea

Misc: falls risk, HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS)

Interactions

Drug-drug:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Keveyis