REMS
Absorption: Rapidly converted to phenytoin after IV administration and completely absorbed after IM administration.
Distribution: Distributes into CSF and other body tissues and fluids. Enters breast milk; crosses the placenta, achieving similar maternal/fetal levels. Preferentially distributes into fatty tissue.
Protein Binding: Fosphenytoin: 9599%; phenytoin: 9095%.
Half-Life: Fosphenytoin: 15 min; phenytoin: 22 hr (range 742 hr).
(anticonvulsant effect)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
IM | unknown | 30 min | up to 24 hr |
IV | 1545 min | 1560 min | up to 24 hr |
Contraindicated in:
Use Cautiously in:
CV: hypotension (with rapid IV administration), tachycardia
Derm: pruritus, ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), purple glove syndrome, rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS
EENT: amblyopia, deafness, diplopia, tinnitus
GI: dry mouth, nausea, taste perversion, tongue disorder, vomiting
Hemat: lymphadenopathy, megaloblastic anemia, pure red cell aplasia
MS: back pain
Neuro: ataxia, dizziness, drowsiness, nystagmus, agitation, brain edema, dysarthria, extrapyramidal syndrome, headache, hypoesthesia, incoordination, paresthesia, stupor, tremor, vertigo
Misc: ANGIOEDEMA, pelvic pain
Drug-drug:
Drug-Natural Products:
Status Epilepticus
Nonemergent and Maintenance Dosing
Lab Test Considerations:
Toxicity and Overdose:
IV Administration: