REMS
Pneumocystis jirovecii
pneumonia (in combination with sulfonamides or dapsone).Absorption: Well absorbed after oral administration.
Distribution: Widely distributed with high concentrations achieved in blood cells, kidneys, lungs, liver, and spleen. Some enters CSF (1326% of serum levels).
Half-Life: 4 days (↓ in patients with HIV).
Contraindicated in:
Use Cautiously in:
Derm: abnormal pigmentation, dermatitis
GI: atrophic glossitis (high doses), anorexia, diarrhea, nausea
GU: hematuria
Hemat: megaloblastic anemia (high doses), neutropenia, pancytopenia, thrombocytopenia
Resp: dry throat, pulmonary eosinophilia
Misc: fever
Drug-drug:
Toxoplasmosis (in Patients without HIV)
Toxoplasmosis (in Patients with HIV)
Lab Test Considerations: