section name header

Pronunciation

a-kli-DIN-ee-um

Classifications

Therapeutic Classification: bronchodilators

Pharmacologic Classification: anticholinergics

Indications

REMS


Action

  • Acts as an anticholinergic by inhibiting the M3 receptor in bronchial smooth muscle.
Therapeutic effects:
  • Bronchodilation with lessened symptoms of COPD.

Pharmacokinetics

Absorption: 6% systemically absorbed following inhalation.

Distribution: Unknown.

Metabolism/Excretion: Rapidly hydrolyzed; metabolites are not pharmacologically active. Metabolites are eliminated in urine (54–65%) and feces (20–33%). 1% excreted unchanged in urine.

Half-Life: 5–8 hr.

Time/Action Profile

(improvement in FEV1)
ROUTEONSETPEAKDURATION
Inhalnwithin 1 hr2–4 hr12 hr





Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

EENT: worsening of narrow-angle glaucoma

GU: urinary retention

Neuro: headache

Resp: paradoxical bronchospasm

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA)

Interactions

Drug-drug:

Route/Dosage

Availability

Assessment

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Tudorza Pressair

Canadian Brand Names

Tudorza Genuair