REMS
Absorption: Systemic absorption follows oral administration. A high-fat meal ↑ absorption.
Distribution: Does not cross the blood-brain barrier.
Half-Life: 611 hr.
Contraindicated in:
Use Cautiously in:
Derm: ↑sweating
GI: abdominal pain, diarrhea, flatulence, GI PERFORATION, nausea, vomiting
Neuro: headache
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANGIOEDEMA), opioid withdrawal
Drug-drug:
Renal Impairment