Secondarily infected traumatic skin lesions (up to 10 cm in length or 100 cm2 area) caused by Staphylococcus aureus and Streptococcus pyogenes.
Action⬆⬇
Inhibits bacterial protein synthesis.
Therapeutic effects:
Inhibition of bacterial growth and reproduction.
Spectrum:
Greatest activity against gram-positive organisms, including:
S. aureus,
Beta-hemolytic streptococci.
Resolution of impetigo.
Eradication of S. aureus carrier state.
Pharmacokinetics⬆⬇
Absorption: Minimal systemic absorption.
Distribution: Remains in the stratum corneum after topical use for prolonged periods of time (72 hr).
Metabolism/Excretion: Metabolized in the skin, removed by desquamation.
Half-Life: 17–36 min.
Time/Action Profile⬆⬇
(anti-infective effect)
ROUTE
ONSET
PEAK
DURATION
Topical‡
unknown
3–5 days
72 hr
‡Resolution of lesions.
Contraind./Precautions⬆⬇
Contraindicated in:
Hypersensitivity to mupirocin or polyethylene glycol.
Use Cautiously in:
Renal impairment;
Burn patients.
Adv. Reactions/Side Effects⬆⬇
Derm: burning, itching, pain, stinging
Interactions⬆⬇
Drug-drug:
None reported.
Route/Dosage⬆⬇
(Adults and Children ≥2 mo): Ointment: Apply 3–5 times daily for 5–14 days.
(Adults and Children ≥3 mo): Cream: Apply small amount 3 times/day for 10 days.
Availability⬆⬇
(Generic available)
Cream: 2%
Ointment: 2%
Assessment⬆⬇
Assess lesions before and daily during therapy.
Implementation⬆⬇
Topical Wash affected area with soap and water and dry thoroughly. Apply a small amount of mupirocin to the affected area 3 times daily and rub in gently. Treated area may be covered with gauze if desired.
Patient/Family Teaching⬆⬇
Instruct patient on the correct application of mupirocin. Advise patient to apply medication exactly as directed for the full course of therapy. If a dose is missed, apply as soon as possible unless almost time for next dose. Avoid contact with eyes.
Topical Teach patient and family appropriate hygienic measures to prevent spread of impetigo.
Instruct parents to notify school nurse for screening and prevention of transmission.
Patient should consult health care professional if symptoms have not improved in 3–5 days.
Evaluation/Desired Outcomes⬆⬇
Healing of skin lesions. If no clinical response is seen in 3–5 days, condition should be re-evaluated.
