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Pronunciation

ROE-pi-vi-kane

Classifications

Therapeutic Classification: epidural local anesthetics, anesthetics (topical/local)

Indications

REMS


Action

  • Local anesthetics inhibit initiation and conduction of sensory nerve impulses by altering the influx of sodium and efflux of potassium in neurons, slowing or stopping pain transmission.
Therapeutic effects:
  • Decreased pain or induction of anesthesia; low doses have minimal effect on sensory or motor function; higher doses may produce complete motor blockade.

Pharmacokinetics

Absorption: Systemic absorption follows epidural administration, but amount absorbed depends on dose.

Distribution: If systemic absorption occurs, this agent is widely distributed and crosses the placenta.

Metabolism/Excretion: Small amounts that may reach systemic circulation are mostly metabolized by the liver; <1% excreted unchanged in the urine.

Half-Life: 4.2 hr (after epidural use).

Time/Action Profile

(analgesia)

ROUTEONSETPEAKDURATION
Epidural10–30 minunknown2–8 hr



Duration of anesthetic block.



Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Interactions

Drug-drug:

Route/Dosage

Surgical Anesthesia

Labor Pain

Postoperative Pain

Availability

(Generic available)

Assessment

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Naropin

Pot. Nursing Diagnoses