Therapeutic Classification: anti-infectives
Pharmacologic Classification: penicillinase resistant penicillins
REMS
Spectrum:
Absorption: IV administration results in complete bioavailability. Moderately absorbed (50%) following oral administration.
Distribution: Widely distributed; penetration into CSF is minimal but sufficient in the presence of inflamed meninges; crosses the placenta and enters breast milk.
Half-Life: 0.51.1 hr (↑ in severe hepatic impairment, renal impairment, and in neonates).
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO | 30 min | 30120 min | 6 hr |
IM | unknown | unknown | 6 hr |
IV | rapid | end of injection/infusion | 6 hr |
Contraindicated in:
Use Cautiously in:
GI: diarrhea, epigastric distress, nausea, vomiting, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD)
GU: interstitial nephritis
Hemat: eosinophilia, leukopenia
Misc: ANAPHYLAXIS AND SERUM SICKNESSALLERGIC REACTIONS INCLUDING , superinfection
Drug-drug:
Lab Test Considerations:
Y-Site Incompatibility: