obiltoxaximab

Absorption: IV administration results in complete bioavailability.

Distribution: Some tissue distribution.

Metabolism/Excretion: No renal clearance.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

(levels)

ROUTE	ONSET	PEAK	DURATION
IV	rapid	end of infusion	unknown

Contraind./Precautions ⬆ ⬇

Contraindicated in:

None noted.

Use Cautiously in:

OB: Safety not established in pregnancy;
Lactation: Safety not established in breastfeeding.

Adv. Reactions/Side Effects ⬆ ⬇

Derm: pruritus

Neuro: headache

Resp: cough, upper respiratory tract infection

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS), injection site reactions

Interactions ⬆ ⬇

Drug-drug:

None reported.

Route/Dosage ⬆ ⬇

IV (Adults and Children >40 kg): 16 mg/kg as single dose.
IV (Adults ≤40 kg): 24 mg/kg as single dose.
IV (Children 16–40 kg): 24 mg/kg as single dose.
IV (Children ≤15 kg): 32 mg/kg as single dose.

Availability ⬆ ⬇

Solution for injection: 100 mg/mL

Assessment ⬆ ⬇

Observe for signs and symptoms of anaphylaxis (rash, pruritus, laryngeal edema, wheezing, urticaria, cough, dysphonia, throat irritation, dizziness, dyspnea, chest discomfort). Discontinue drug and notify health care professional immediately if these problems occur. Keep epinephrine, an antihistamine, and resuscitation equipment close by in case of an anaphylactic reaction.

Implementation ⬆ ⬇

Pre-medicate with diphenhydramine prior to administering.

IV Administration:

Keep vial in carton to protect from light before preparing. Solution is clear to opalescent, colorless to pale yellow to pale brownish yellow, may contain few translucent-to-white proteinaceous particulates; do not administer solutions that are discolored or contain particulate matter.
Adults: Diluent: Dilute in 250 mL 0.9% NaCl. Invert to mix; do not shake. Solution is stable for up to 8 hrs at room temperature.Concentration: 100 mg/mL.Children and Adults weighing <40 kgDiluent: Dilute in 100 mL or 250 mL of 0.9% NaCl. Invert to mix; do not shake. Solution is stable for up to 8 hrs at room temperature.Concentration: 100 mg/mL.Syringe for infusionDiluent: Dilute dose in 0.9% NaCl.Concentration: 100 mg/mL.Administer immediately; do not store solution in syringe.
Rate: Infuse through a 0.22 micron in-line filter. Flush line with 0.9% NaCl and end of infusion. For adults, infuse over 90 min at a rate of 167 mL/hr. For children and adults weighing >15 kg–40 kg, infuse at a rate of 167 mL/hr for 250 mL or 67 mL/hr for 100 mL infusion. For children ≤15 kg, infuse 100 mL at a rate of 67 mL/hr; 50 mL at 33.3 mL/hr; 25 mL at 17 mL/hr; 20 mL at 13.3 mL/hr; 15 mL at 10 mL/hr; and 7 mL at 4.7 mL/hr.

Patient/Family Teaching ⬆ ⬇

Explain purpose of medication to patient.
Instruct patient to notify health care professional immediately if signs and symptoms of hypersensitivity reaction occur.
Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breast feeding.

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Pronunciation ⬇

Classifications ⬆ ⬇

Indications ⬆ ⬇

Action ⬆ ⬇

Pharmacokinetics ⬆ ⬇