section name header

Pronunciation

neff-A-zoe-done

Classifications

Therapeutic Classification: antidepressants

Indications

REMS

Unlabeled Uses:

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: Well absorbed but undergoes extensive and variable first-pass hepatic metabolism (bioavailability about 20%).

Distribution: Widely distributed; enters the CNS.

Protein Binding: ge.gif99%.

Metabolism/Excretion: Extensively metabolized. One metabolite (hydroxynefazodone) has antidepressant activity.

Half-life: Nefazodone: 2–4 hr; hydroxynefazodone: 1.5–4 hr.

Time/Action Profile

(antidepressant action)

ROUTEONSETPEAKDURATION
POdays–wkseveral wkunknown

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: bradycardia, hypotension.

Derm: rash.

EENT: abnormal vision, blurred vision, eye pain, tinnitus.

GI: constipation, dry mouth, nausea, gastroenteritis, HEPATOTOXICITY.

GU: erectile dysfunction.

Hemat: hematocrit.

Neuro: dizziness, insomnia, somnolence, agitation, confusion, SUICIDAL THOUGHTS, weakness.

Resp: dyspnea.

Interactions

Drug-Drug:

Drug-Natural Products:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Serzone