section name header

Pronunciation

NOR-ep-i-nef-rin

Classifications

Therapeutic Classification: vasopressors

Indications

High Alert

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: IV administration results in complete bioavailability.

Distribution: Concentrates in sympathetic nervous tissue. Does not cross the blood-brain barrier but readily crosses the placenta.

Metabolism/Excretion: Taken up and metabolized rapidly by sympathetic nerve endings.

Half-life: Unknown.

Time/Action Profile

(effects on BP)

ROUTEONSETPEAKDURATION
IVimmediaterapid1–2 min

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: arrhythmia, bradycardia, chest pain, hypertension.

Endo: hyperglycemia.

F and E: metabolic acidosis.

GU: urine output, renal failure.

Local: phlebitis at IV site.

Neuro: anxiety, dizziness, headache, insomnia, restlessness, tremor, weakness.

Resp: dyspnea.
Misc: fever.

Interactions

Drug-Drug:

Route/Dosage

see Calculator

Availability

(Generic available)

Assessment

Toxicity and Overdose:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Levophed