section name header

Pronunciation

peg-VIS-o-mant

Classifications

Therapeutic Classification: hormones

Pharmacologic Classification: growth hormones

Indications

REMS


Action

  • Binds to growth hormone (GH) receptor sites on cell surfaces, blocking the effects of endogenous growth hormone.
  • Bound to polyethylene glycol (PEG) to reduce clearance and increase duration of action.
Therapeutic effects:
  • Decreased manifestations of acromegaly and normalized insulin-like growth factor-1 (IGF-1) levels.

Pharmacokinetics

Absorption: 57% absorbed following SUBQ administration.

Distribution: Does not distribute extensively into tissues.

Metabolism/Excretion: Unknown.

Half-Life: 6 days.

Time/Action Profile

(effects on IGF-1)

ROUTEONSETPEAKDURATION
SUBQwithin 2 wk4–6 wkunknown





Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: hypertension, peripheral edema

Derm: lipohypertrophy

Endo: glucose tolerance, growth hormone deficiency

GI: liver enzymes

GU: fertility

MS: back pain

Misc: hypersensitivity reactions (including anaphylaxis and angioedema)

Interactions

Drug-drug:

Route/Dosage

Availability

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Somavert