Absorption: 60% absorbed following oral administration (high-fat meal may ↓ absorption).
Distribution: Widely distributed to tissues..
Protein Binding: 97%.
Half-Life: Quinapril:0.8 hrQuinaprilat: 3 hr (↑ in renal impairment).
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO | within 1 hr | 24 hr | up to 24 hr |
‡Full effects may not be noted for several wk.
Contraindicated in:
Use Cautiously in:
CV: hypotension, chest pain
Derm: rash
F and E: hyperkalemia
GI: abdominal pain, diarrhea, nausea, vomiting
GU: renal impairment
MS: back pain, myalgia
Neuro: dizziness, fatigue, headache
Misc: ANGIOEDEMA
Drug-drug:
Hypertension
Renal Impairment
Renal Impairment
Lab Test Considerations: