Therapeutic Classification: anticoagulants
Pharmacologic Classification: low molecular weight heparins
Absorption: 100% absorbed after SUBQ administration; IV administration results in complete bioavailability.
Distribution: Unknown.
Metabolism/Excretion: Excreted mostly by the kidneys.
Half-Life: 25 hr.
Prophylaxis of DVT (non HIT patients)
HIT
- SC (Adults ): 750 anti-factor Xa IU every 12 hr starting 14 hr preop and at least 2 hr postop for 710 days or until ambulatory (up to 14 days). Prophylaxis of DVT following Orthopedic, Major Abdominal Surgery, and Thoracic Surgery: 750 anti-factor Xa units, twice daily up to 14 days, initiate 14 hr preop.
- IV SC (Adults ): Prophylaxis of Deep Vein Thrombosis in Non-hemorrhagic Stroke Patients: up to 1000 anti-Xa units IV, followed by 750 anti-Xa units subcutaneously, twice daily for 714 days.
- IV SC (Adults ): DVT prophylaxis, current HIT, ≤90 kg: 750 anti-Xa units SC two or three times daily for 710 days (initial bolus of 1250 anti-Xa units IV may be used); DVT prophylaxis, current HIT, >90 kg: 1250 anti-Xa units SC two or three times daily for 710 days (initial bolus of 1250 anti-Xa units IV may be used); DVT prophylaxis, past (>3 mo) HIT, ≤90 kg: 750 anti-Xa units SC two or three times daily for 710 days; DVT prophylaxis, past (>3 mo) HIT, >90 kg: 750 anti-Xa units SC three times daily or 1250 anti-Xa units SC twice daily for 710 days; Established pulmonary embolism or DVT, thrombus <5 days, >90 kg: 3750 anti-Xa units IV bolus, then 400 anti-Xa units/hr for 4 hr, then 300 anti-Xa units/hr for 4 hr, then 150200 anti-Xa units/hr for 57 days or 1750 anti-Xa units SC twice daily for 47 days; Established pulmonary embolism or DVT, thrombus <5 days, 5590 kg: 22502500 anti-Xa units IV bolus, then 400 anti-Xa units/hr for 4 hr, then 300 anti-Xa units/hr for 4 hr, then 150200 anti-Xa units/hr for 57 days or 2000 anti-Xa units SC twice daily for 47 days; Established pulmonary embolism or DVT, thrombus <5 days, <55 kg: 12501500 anti-Xa units IV bolus, then 400 anti-Xa units/hr for 4 hr, then 300 anti-Xa units/hr for 4 hr, then 150200 anti-Xa units/hr for 57 days or 1500 anti-Xa units SC twice daily for 47 days; Established pulmonary embolism or DVT, thrombus ≥5 days, >90 kg: 1250 anti-Xa units IV bolus, then 750 anti-Xa units SC three times daily or 1250 anti-Xa units twice daily; Established pulmonary embolism or DVT, thrombus ≥5 days, ≤90 kg: 1250 anti-Xa units IV bolus, then 750 anti-Xa units SC 23 times daily; Surgical prophylaxis, nonvascular surgery, >90 kg: 750 anti-Xa units SC 14 hr before procedure, repeat ≥6 hr after procedure, then 1250 anti-Xa units SC twice daily for 710 days; Surgical prophylaxis, nonvascular surgery, ≤90 kg: 750 anti-Xa units SC 14 hr before procedure, repeat ≥6 hr after procedure, then 750 anti-Xa units SC twice daily for 710 days; Surgical prophylaxis, embolectomy, >90 kg: 22502500 anti-Xa units IV bolus before procedure, then 150200 anti-Xa units/hr IV starting ≥6 hr after procedure for 57 days or 750 anti-Xa units 23 times daily or change to oral anticoagulants after several days; Surgical prophylaxis, embolectomy, 5590 kg: 22502500 anti-Xa units IV bolus before procedure, then 1250 anti-Xa units SC twice daily starting ≥6 hr after procedure, then 750 anti-Xa units 23 times daily or change to oral anticoagulants after several days; Cardiac catheterization >90 kg: 3750 anti-Xa units IV bolus prior to procedure; Cardiac catheterization <90 kg: 2500 anti-Xa units IV bolus prior to procedure; Percutaneous transluminal coronary angioplasty: 2500 anti-Xa units IV prior to procedure, then 150200 anti-Xa units/hr IV for 12 days after procedure, may be followed by 750 anti-Xa units SC for several days; Intra-aortic balloon pump catherization, >90 kg: 3750 anti-Xa units IV bolus before procedure, then 150200 anti-Xa units/hr IV or a 2nd bolus of 1250 anti-Xa units IV or 750 anti-Xa units SC two or three times daily or 1250 anti-Xa units SC twice daily; Intra-aortic balloon pump catherization, <90 kg: 2500 anti-Xa units IV bolus before procedure, then 150200 anti-Xa units/hr IV or a 2nd bolus of 1250 anti-Xa units IV or 750 anti-Xa units SC two or three times daily or 1250 anti-Xa units SC twice daily; Peripheral vascular bypass: 22502500 anti-Xa units IV bolus before procedure, then 150200 anti-Xa units/hr IV started ≥6 hr after procedure for 57 days or 750 anti-Xa units SC two or three times daily or change to oral anticoagulants; Hemodialysis, every other day or less frequently: 3750 anti-Xa units IV bolus before first 2 hemodialysis, then 3000 anti-Xa units IV bolus (if plasma antifactory Xa level <300 U/L) or 2500 anti-Xa units IV (if plasma antifactory Xa levels 350400); Hemodialysis, every other day or less frequently, <55kg: 2500 anti-Xa units IV bolus before first 2 hemodialysis, then 2000 anti-Xa units IV bolus (if plasma antifactory Xa level <300 U/L), or 1500 anti-Xa units IV (if plasma antifactory Xa levels 350400); Hemodialysis, daily: 3750 anti-Xa units IV before first dialysis, then 2500 before second dialysis; Hemodialysis, daily, <55kg: 2500 anti-Xa units IV before first dialysis, then 2000 before second dialysis; Hemofiltration, 5590kg: 2500 anti-Xa units IV bolus, then 600/h for 4h, then 400/h for 4/h, then 200600/h to maintain plasma antifactory Xa levels of 5001000 U/L; Hemofiltration, <55kg: 2000 anti-Xa units IV bolus, then 400/h for 4h, then 150400/h to maintain plasma antifactory Xa levels of 5001000 U/L.