section name header

Pronunciation

sef-TAY-zi-deem/a-vi-BAK-tam

Classifications

Therapeutic Classification: anti-infectives

Pharmacologic Classification: third generation cephalosporins, beta lactamase inhibitors

Indications

REMS


Action

  • Ceftazidime: Binds to the bacterial cell wall membrane, causing cell death.
  • Avibactam: Inhibits beta-lactamase, an enzyme that destroys penicillins and cephalosporins.
Therapeutic effects:
  • Death of susceptible bacteria with resolution of infection.

Spectrum:

Pharmacokinetics

Ceftazidime

Absorption: IV administration results in complete bioavailability.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Minimally metabolized; 80–90% excreted unchanged in urine.

Half-Life: 2.8–3.3 hr ( in renal impairment).

Avibactam

Absorption: IV administration results in complete bioavailability.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Minimally metabolized, mainly excreted unchanged in urine.

Half-Life: 2.2–2.7 hr.

Time/Action Profile

(plasma concentrations)

ROUTEONSETPEAKDURATION
IVrapidend of infusion8 hr ( in renal impairment)





Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Interactions

Drug-drug:

Route/Dosage

Renal Impairment

Renal Impairment

Availability

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Avycaz