section name header

Pronunciation

gem-FYE-broe-zil

Classifications

Therapeutic Classification: lipid-lowering agents

Pharmacologic Classification: fibric acid derivatives

Indications

REMS

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: Well absorbed after oral administration.

Distribution: Unknown.

Metabolism/Excretion: Some metabolism by the liver, 70% excreted by the kidneys (mostly unchanged), 6% excreted in feces.

Half-life: 1.3–1.5 hr.

Time/Action Profile

(triglyceride-lowering effect)

ROUTEONSETPEAKDURATION
PO2–5 days4 wkseveral mo

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: alopecia, rash, urticaria.

EENT: blurred vision.

GI: abdominal pain, diarrhea, epigastric pain, flatulence, gallstones, heartburn, nausea, vomiting.

Hemat: anemia, leukopenia.

MS: myositis.

Neuro: dizziness, headache.

Interactions

Drug-Drug:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Lopid