section name header

Pronunciation

dye-METH-uhl sul-FOK-side

Classifications

Therapeutic Classification: none.assigned

Indications

Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.

REMS


Unlabeled Use:
  • Amyloidosis.
  • Prevention of extravasation injury from antineoplastic agents.

Action

  • Stimulates bladder afferent pathways, causing release of nitrogen oxide from afferent neurons which controls lower urinary tract function. Also has anti-inflammatory, anti-ischemic analgesic, and vasodilatory properties.
Therapeutic effects:
  • Improved symptoms of interstitial cystitis.
  • Prevention of tissue necrosis from extravasation injuries.

Pharmacokinetics

Absorption: Easily penetrates the skin.

Distribution: Widely distributed in body fluids and tissues.

Metabolism/Excretion: Metabolized to dimethyl sulfone and dimethyl sulfide.

Half-Life: Unknown.

Time/Action Profile

ROUTEONSETPEAKDURATION
PO, Topical, Intravesicularunknown4 hrunknown



Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: dry skin, pruritus

GI: diarrhea, nausea, vomiting

GU: bladder discomfort

Hemat: eosinophilia

Neuro: dizziness, headache, sedation

Misc: garlic-like breath/body odor

Interactions

Natural-Drug Products:

Natural-Natural Products:

Route/Dosage

Availability

Assessment

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

DMSO