section name header

Pronunciation

AR-sen-ik trye-OX-ide

Classifications

Therapeutic Classification: antineoplastics

Pharmacologic Classification: heavy metals

Indications

High Alert

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: IV administration results in complete bioavailability.

Distribution: Arsenic is stored in liver, kidney, heart, lung, hair and nails.

Metabolism/Excretion: Converted from pentavalent arsenic to trivalent arsenic by arsenate reductase and further converted by methyltransferases in the liver. Methylated arsenic is excreted in urine.

Half-life: Unknown.

Time/Action Profile

(effect on hematologic parameters)

ROUTEONSETPEAKDURATION
IVunknownunknownunknown

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: QT interval prolongation, atrial arrhythmias, COMPLETE HEART BLOCK, TORSADE DE POINTES.

Derm: dermatitis.

Endo: hyperglycemia, hypoglycemia.

F and E: acidosis, hyperkalemia, hypocalcemia, hypokalemia, hypomagnesemia.

GI: liver enzymes, abdominal pain, constipation.

GU: fertility (males), renal failure.

Hemat: differentiation syndrome, leukocytosis, anemia, DISSEMINATED INTRAVASCULAR COAGULATION, NEUTROPENIA, THROMBOCYTOPENIA.

MS: back pain, arthralgia, bone pain, limb pain, myalgia, neck pain.

Neuro: ENCEPHALOPATHY (INCLUDING WERNICKE'S ENCEPHALOPATHY), fatigue, headache, insomnia, POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME (PRES), weakness.

Resp: hypoxia, dyspnea, pleural effusion.
Misc: fever, hypersensitivity reactions, infection/sepsis, MALIGNANCY.

Interactions

Drug-Drug:

Route/Dosage

see Calculator

Newly Diagnosed Low-Risk APL

Relapsed or Refractory APL

Availability

(Generic available)

Assessment

Lab Test Considerations: Toxicity and Overdose:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Trisenox