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Pronunciation

pen-SYE-kloe-veer

Classifications

Therapeutic Classification: antivirals (topical)

Indications

REMS


Action

  • Inhibits viral DNA synthesis and replication.
Therapeutic effects:
  • Death of herpes virus.
  • Decreased lesion duration and pain.
  • Active against herpes viruses.

Pharmacokinetics

Absorption: Not absorbed following topical use.

Distribution: Unknown.

Metabolism/Excretion: Converted intracellularly to active triphosphate form; excreted in urine.

Half-Life: 2–2.5 hr.

Time/Action Profile

ROUTEONSETPEAKDURATION
Topicalunknownunknownunknown





Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Local: application site reactions

Neuro: headache

Interactions

Drug-drug:

Route/Dosage

Availability

(Generic available)

Assessment

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Denavir