REMS
Absorption: Rapidly converted from prodrug form (adefovir dipivoxil) to adefovir following oral administration; 59% bioavailable.
Distribution: 0.350.39 L/kg.
Half-Life: 7.5 hr.
Contraindicated in:
Use Cautiously in:
Derm: pruritus, rash
F and E: LACTIC ACIDOSIS
GI: ↑liver enzymes, abdominal pain, diarrhea, dyspepsia, flatulence, HEPATOMEGALY WITH STEATOSIS, nausea, vomiting
GU: hematuria, nephrotoxicity
MS: weakness
Neuro: headache
Resp: cough, pharyngitis, sinusitis
Misc: HIV resistance, fever
Drug-drug:
Renal Impairment
Lab Test Considerations: