section name header

Pronunciation

kloe-TRIM-a-zole

Classifications

Therapeutic Classification: antifungals (oral, nonabsorbed)

Indications

REMS

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: Minimal systemic absorption.

Distribution: Inhibitory concentrations remain in saliva for up to 3 hr after troche dissolves.

Metabolism/Excretion: Metabolized by liver; <1% excreted unchanged in urine.

Half-life: 24 hr.

Time/Action Profile

ROUTEONSETPEAKDURATION
POunknownunknownup to 3 hr

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: pruritis.

GI: liver function tests, abnormal mouth sensations, nausea, vomiting.

Interactions

Drug-Drug:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Mycelex