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Pronunciation

meth-oh-try-MEP-ra-zeen

Classifications

Therapeutic Classification: antipsychotics, nonopioid analgesics

Pharmacologic Classification: phenothiazines

Indications

REMS


Action

  • Sedation.
Therapeutic effects:
  • Reduction in severity of pain.

Pharmacokinetics

Absorption: Well absorbed after PO/IM administration. IV administration results in complete bioavailability.

Distribution: Enters CSF and crosses the placenta. Minimal amounts enter breast milk.

Metabolism/Excretion: Mostly metabolized by the liver. Some metabolites are active; 1% excreted unchanged by the kidneys.

Half-Life: 15–30 hr.

Time/Action Profile

ROUTEONSETPEAKDURATION
PO (blood levels)unknown2.7–2.9 hr8–12 hr
IM (analgesia)unknown20–40 min8 hr (up to 24 hr in children)



Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CNS: amnesia, drowsiness, excess sedation, disorientation, euphoria, extrapyramidal reactions, headache, NEUROLEPTIC MALIGNANT SYNDROME, SEIZURES, slurred speech, tardive dyskinesia, weakness.

EENT: nasal congestion

CV: orthostatic hypotension, bradycardia, palpitations, tachycardia

GI: constipation, abdominal discomfort, dry mouth, nausea, vomiting

GU: difficulty in urination

Endo: hyperglycemia, hyperprolactinemia

Hemat: blood dyscrasias

Local: pain at injection site

Misc: chills

Interactions

Drug-drug:

Drug-Natural Products:

Route/Dosage

Availability

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

Canadian Brand Names

Methoprazine, Nozinan