section name header

Pronunciation

ox-i-TOE-sin

Classifications

Therapeutic Classification: hormones

Pharmacologic Classification: oxytocics

Indications

IM:

High Alert


Action

  • Stimulates uterine smooth muscle, producing uterine contractions similar to those in spontaneous labor.
  • Has vasopressor and antidiuretic effects.
Therapeutic effects:
  • Induction of labor.
  • Control of postpartum bleeding.

Pharmacokinetics

Absorption: IV administration results in complete bioavailability.

Distribution: Widely distributed in extracellular fluid. Small amounts reach fetal circulation.

Metabolism/Excretion: Rapidly metabolized by liver and kidneys. Primarily excreted in urine as metabolites.

Half-Life: 3–9 min.

Time/Action Profile

(reduction in uterine contractions)

ROUTEONSETPEAKDURATION
IVimmediateunknown1 hr
IM3–5 minunknown30–60 min





Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Maternal adverse reactions are noted for IV use only

CV:

maternal

hypotension,

fetal

arrhythmias

F and E:

maternal

hypochloremia, hyponatremia, water intoxication

GU:

maternal

uterine motility, painful contractions, abruptio placentae, uterine blood flow

Neuro:

maternal

COMA, SEIZURES,

fetal

INTRACRANIAL HEMORRHAGE

Resp:

fetal

ASPHYXIA, hypoxia

Misc: hypersensitivity reactions

Interactions

Drug-drug:

Route/Dosage

Induction/Stimulation of Labor

Postpartum Hemorrhage

Incomplete/Inevitable Abortion

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

IV Administration:

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Pitocin