REMS
Absorption: High-fat, high-calorie food ↑ drug exposure.
Distribution: Extensively distributed to extravascular tissues.
Half-Life: 1617 hr.
Contraindicated in:
Use Cautiously in:
Reflect side effects experienced with combination regimen of pretomanid, bedaquiline, and linezolid.
CV: hypertension, QT interval prolongation
Derm: acne, pruritus, rash, dry skin
EENT: visual impairment, optic neuropathy
Endo: hypoglycemia, hyperglycemia
F and E: hyperkalemia, hypokalemia, hypomagnesemia, hyponatremia, LACTIC ACIDOSIS
GI: abdominal pain, dyspepsia, ↑amylase, diarrhea, nausea, vomiting, constipation, gastritis, HEPATOTOXICITY, ↑lipase, PANCREATITIS
GU: ↓fertility (males), ↑serum creatinine, testicular abnormalities
Hemat: anemia, leukopenia, NEUTROPENIA, thrombocytopenia
MS: ↑creatine kinase, pain
Neuro: headache, peripheral neuropathy, dizziness, dysgeusia, insomnia, SEIZURES
Resp: cough, hemoptysis, lower respiratory tract infection, pleuritic pain
Drug-drug:
Drug-Natural Products:
Lab Test Considerations: