Spectrum:
Absorption: 59% absorbed after oral administration; IV administration results in complete bioavailability.
Distribution: Widely distributed.
Half-Life: 3.7 hr (IV); 4.28.5 hr (PO).
Contraindicated in:
Use Cautiously in:
CV: AORTIC ANEURYSM/DISSECTION
Endo: hyperglycemia, hypoglycemia
GI: ↑liver enzymes, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), diarrhea, nausea, vomiting
MS: arthralgia, myalgia, tendinitis, tendon rupture
Neuro: agitation, anxiety, attention disturbances, confusion, delirium, depression, disorientation, dizziness, ELEVATED INTRACRANIAL PRESSURE (INCLUDING PSEUDOTUMOR CEREBRI), hallucinations, headache, insomnia, memory impairment, nightmares, paranoia, peripheral neuropathy, SEIZURES, SUICIDAL THOUGHTS/BEHAVIORS, toxic psychosis, tremor
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS, ANGIOEDEMA, AND URTICARIA)
Drug-drug:
Acute Bacterial Skin and Skin Structure Infections
Community-Acquired Bacterial Pneumonia
Renal Impairment
Renal Impairment
Clostridioides difficile
-associated diarrhea (CDAD). May begin up to several wk following cessation of therapy.Lab Test Considerations:
IV Administration: