section name header

Pronunciation

trye-AM-ter-een

Classifications

Therapeutic Classification: diuretics (potassium-sparing)

Indications

REMS

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: 30–70% absorbed.

Distribution: Widely distributed.

Metabolism/Excretion: 80% metabolized by the liver, some excretion of unchanged drug.

Half-life: 1.7–2.5 hr.

Time/Action Profile

(diuretic effect)

ROUTEONSETPEAKDURATION
2–4 hr1–several days7–9 hr

†Single dose.

†Multiple doses.

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: arrhythmias.

Derm: photosensitivity.

F and E: hyperkalemia, hyponatremia.

GI: nausea, vomiting.

GU: bluish urine, erectile dysfunction, nephrolithiasis.

Hemat: blood dyscrasias.

MS: muscle cramps.

Neuro: dizziness.
Misc: (INCLUDING ANAPHYLAXIS)HYPERSENSITIVITY REACTIONS .

Interactions

Drug-Drug:

Route/Dosage

see Calculator

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Dyrenium