REMS
Streptococcal pneumoniae
septicemia in children with sickle-cell disease.Spectrum:
Absorption: Variably absorbed from the GI tract. Resists acid degradation in the GI tract.
Distribution: Widely distributed, although CNS penetration is poor in the presence of normal (non-inflamed) meninges. Crosses the placenta and enters breast milk.
Protein Binding: 60%.
Half-Life: 3060 min.
Contraindicated in:
Use Cautiously in:
GI: diarrhea, epigastric distress, nausea, vomiting, Clostridioides difficile-associated diarrhea (CDAD)
GU: interstitial nephritis
Hemat: eosinophilia, leukopenia
Neuro: SEIZURES
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND SERUM SICKNESS) , superinfection
Drug-drug:
Streptococcus pneumoniae
sepsis in children with sickle cell disease125 mg twice daily.Lab Test Considerations: