section name header

Pronunciation

trye-METH-oh-prim

Classifications

Therapeutic Classification: anti-infectives

Pharmacologic Classification: folate antagonists

Indications

REMS

Unlabeled Uses:

Action

Therapeutic Effects:

Spectrum:

Pharmacokinetics

Absorption: Well absorbed following oral administration.

Distribution: Widely distributed.

Metabolism/Excretion: 80% excreted unchanged in the urine; 20% metabolized by the liver.

Half-life: 8–11 hr ( in renal impairment).

Time/Action Profile

(plasma concentrations)

ROUTEONSETPEAKDURATION
POrapid1–4 hr12–24 hr

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: pruritus, rash.

GI: altered taste, epigastric discomfort, glossitis, nausea, vomiting, drug-induced hepatitis.

Hemat: megaloblastic anemia, neutropenia, thrombocytopenia.
Misc: fever.

Interactions

Drug-Drug:

Route/Dosage

see Calculator

Urinary Tract Infections

Renal Impairment

Otitis Media

Prophylaxis of Chronic Urinary Tract Infections

Pneumocystis jirovecii Pneumonia

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Primsol