section name header

Pronunciation

eff-in-a-KON-a-zole

Classifications

Therapeutic Classification: antifungals

Pharmacologic Classification: triazoles

Indications

REMS


Action

  • Inhibits synthesis of ergosterol, a component of fungal cell membranes.
Therapeutic effects:
  • Resolution of toenail fungus.

Spectrum:

Pharmacokinetics

Absorption: Minimal systemic absorption follows application to toenails.

Distribution: Unknown.

Metabolism/Excretion: Unknown.

Half-Life: 29.9 hr.

Time/Action Profile

ROUTEONSETPEAKDURATION
Topicalunknownunknownunknown



Prolonged treatment is necessary due to need for treatment throughout growth of new toenails.



Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Local: application site dermatitis, application site pain, application site vesicles, ingrown toenail

Interactions

Drug-drug:

Route/Dosage

Availability

(Generic available)

Assessment

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Jublia