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Pronunciation

SIL-ver sul-fa-DYE-a-zeen

Classifications

Therapeutic Classification: anti-infectives (topical)

Pharmacologic Classification: sulfonamides

Indications

REMS


Unlabeled Use:
  • Management of:
    • Minor skin infections,
    • Dermal ulcers.

Action

  • Splits to produce bactericidal concentrations of silver and sulfadiazine.
  • Action is at level of cell membrane and cell wall.
Therapeutic effects:
  • Bactericidal action against organisms found in burns.

Spectrum:

Pharmacokinetics

Absorption: Small amounts of silver are systemically absorbed following topical application. Up to 10% of sulfadiazine is absorbed.

Distribution: Unknown.

Metabolism/Excretion: Absorbed sulfadiazine is excreted unchanged by the kidneys.

Half-Life: Unknown.

Time/Action Profile

(anti-infective action)

ROUTEONSETPEAKDURATION
Topicalon contactunknownas long as applied





Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: burning, EXFOLIATIVE DERMATITIS, itching, pain, rash, skin discoloration, skin necrosis, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS

Hemat: leukopenia

Interactions

Drug-drug:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Flint SSD, Sildimac, Silvadene, Thermazene

Canadian Brand Names

Dermazin, Flamazine