section name header

Pronunciation

ah-BACK-ah-veer

Classifications

Therapeutic Classification: antiretrovirals

Pharmacologic Classification: nucleoside reverse transcriptase inhibitors

Indications

REMS

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: Rapidly and extensively (83%) absorbed.

Distribution: Distributes into extravascular space and readily distributes into erythrocytes.

Metabolism/Excretion: Mostly metabolized by the liver; 1.2% excreted unchanged in urine.

Half-life: 1.5 hr.

Time/Action Profile

(blood levels)

ROUTEONSETPEAKDURATION
POunknownunknownunknown

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: MYOCARDIAL INFARCTION.

Derm: rash.

F and E: LACTIC ACIDOSIS.

GI: diarrhea, nausea, vomiting, anorexia, HEPATOMEGALY (WITH STEATOSIS).

Neuro: headache, insomnia.
Misc: HYPERSENSITIVITY REACTIONS, immune reconstitution syndrome.

Interactions

Drug-Drug:

Route/Dosage

see Calculator

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Ziagen