Absorption: Well absorbed (≥88%) following oral administration.
Distribution: Well distributed to extravascular tissues.
Half-Life: 5060 hr.
Contraindicated in:
Use Cautiously in:
CV: palpitations, QT interval shortening
Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), pruritus, rash
EENT: diplopia, blurred vision, nystagmus, pharyngitis, vertigo, visual impairment
F and E: hyperkalemia
GI: ↑liver enzymes, abdominal pain, constipation, diarrhea, dry mouth, dysgeusia, dyspepsia, nausea, vomiting
GU: dysmenorrhea, pain, urinary tract infection
Neuro: dizziness, headache, somnolence, amnesia, aphasia, ataxia, attention disturbance, confusion, disorientation, dysarthria, euphoria, irritability, memory impairment, slowness of thoughts, SUICIDAL THOUGHTS/BEHAVIORS, tremor
Resp: dyspnea, hiccups
Misc: fatigue, physical dependence
Drug-drug:
Hepatic Impairment