REMS
Absorption: IV administration results in complete bioavailability.
Distribution: Widely distributed; enters CSF.
Protein Binding: 12%.
Half-Life: Adults: 2.9 hr; Children 9 mo12 yr: 2.4 ±0.7 hr; Neonates: 2.4 hr (↑ in renal impairment).
Contraindicated in:
Use Cautiously in:
CV: arrhythmias, edema, hypertension, hypotension
Derm: alopecia, photosensitivity, pruritus, rash, urticaria
Endo: hypoglycemia
GI: ↑liver enzymes, abdominal pain, GI BLEEDING, nausea, vomiting
GU: ↓fertility, gonadal suppression, hematuria, renal impairment
Hemat: neutropenia, thrombocytopenia, anemia, eosinophilia
Local: pain/phlebitis at IV site
Neuro: abnormal dreams, ataxia, confusion, dizziness, drowsiness, headache, malaise, nervousness, SEIZURES, tremor
Resp: dyspnea
Misc: fever
Drug-drug:
Renal Impairment
Lab Test Considerations:
IV Administration: