section name header

Pronunciation

e-TRA-veer-een

Classifications

Therapeutic Classification: antiretrovirals

Pharmacologic Classification: non nucleoside reverse transcriptase inhibitors

Indications

REMS

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: Well absorbed following oral administration. Food enhances absorption.

Distribution: Unknown.

Protein Binding: 99.9%.

Metabolism/Excretion: Mostly metabolized by the liver (CYP3A4, CYP2C9, and CYP2C19 isoenzymes); minimal renal excretion; mostly eliminated in feces as unchanged drug and metabolites.

Half-life: 41 hr.

Time/Action Profile

(blood levels)

ROUTEONSETPEAKDURATION
POunknown2.5–4 hr12 hr

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: angina pectoris, atrial fibrillation, hypertension, MYOCARDIAL INFARCTION.

Derm: rash, DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), ERYTHEMA MULTIFORME, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS.

EENT: blurred vision, vertigo.

Endo: gynecomastia, hyperglycemia, hyperlipidemia.

GI: nausea, abdominal pain, anorexia, dry mouth, HEPATIC FAILURE, hepatitis, stomatitis, vomiting.

GU: renal failure.

Hemat: anemia, hemolytic anemia.

Metab: fat redistribution.

MS: hemarthrosis.

Neuro: anxiety, confusion, fatigue, headache, insomnia, peripheral neuropathy, SEIZURES, sleep disorders.
Misc: immune reconstitution syndrome.

Interactions

Drug-Drug:

Drug-Natural Products:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Intelence