section name header

Pronunciation

fe-LOE-di-peen

Classifications

Therapeutic Classification: antianginals, antihypertensives

Pharmacologic Classification: calcium channel blockers

Indications

REMS

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: Well absorbed after oral administration but extensively metabolized, resulting in bioavailability.

Distribution: Unknown.

Protein Binding: >99%.

Metabolism/Excretion: Mostly metabolized; minimal amounts excreted unchanged by kidneys.

Half-life: 11–16 hr.

Time/Action Profile

(antihypertensive effect)

ROUTEONSETPEAKDURATION
PO1 hr2–4 hrup to 24 hr

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: peripheral edema, ARRHYTHMIAS, chest pain, HF, hypotension, palpitations, syncope, tachycardia.

Derm: sweating, dermatitis, erythema multiforme, flushing, photosensitivity, pruritus/urticaria, rash, STEVENS-JOHNSON SYNDROME (SJS).

EENT: blurred vision, disturbed equilibrium, epistaxis, tinnitus.

Endo: gynecomastia, hyperglycemia.

GI: liver enzymes, anorexia, constipation, diarrhea, dry mouth, dyspepsia, gingival hyperplasia, nausea, vomiting.

GU: dysuria, nocturia, polyuria, sexual dysfunction, urinary frequency.

Hemat: anemia, leukopenia, thrombocytopenia.

Metab: weight gain.

MS: joint stiffness, muscle cramps.

Neuro: headache, abnormal dreams, anxiety, confusion, dizziness, drowsiness, dysgeusia, paresthesia, psychiatric disturbances, tremor, weakness.

Resp: cough, dyspnea.

Interactions

Drug-Drug:

Drug-Food:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

Canadian Brand Names

Plendil