Therapeutic Classification: antihypertensives
Pharmacologic Classification: peripherally acting antiadrenergics
BEERS REMS
Absorption: Well absorbed following oral administration.
Distribution: Unknown.
Protein Binding: 9899%.
Half-Life: 22 hr.
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO‡ | 12 hr | 26 hr | 24 hr |
PO-XL‡ | 5 wk | unknown | unknown |
‡Antihypertensive effect.
‡Improved urinary flow and BPH symptoms.
Contraindicated in:
Use Cautiously in:
CV: first-dose orthostatic hypotension, arrhythmias, chest pain, edema, palpitations
Derm: flushing, rash, urticaria
EENT: blurred vision, conjunctivitis, epistaxis, intraoperative floppy iris syndrome
GI: abdominal discomfort, constipation, diarrhea, dry mouth, flatulence, nausea, vomiting
GU: ↓libido, priapism, sexual dysfunction
MS: arthralgia, myalgia
Neuro: dizziness, headache, depression, drowsiness, fatigue, nervousness, weakness.
Resp: dyspnea
Drug-drug:
Hypertension