section name header

Pronunciation

SAM-ee

Classifications

Therapeutic Classification: antidepressants

Indications

Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.

REMS

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: Rapidly and extensively metabolized following oral administration.

Distribution: Unknown.

Metabolism/Excretion: Actively metabolized by the liver.

Half-life: 100 min.

Time/Action Profile

(antidepressant action)

ROUTEONSETPEAKDURATION
PO (depression)1–2 wkunknownunknown
PO (osteoarthritis)30 daysunknownunknown

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

GI: diarrhea, flatulence, vomiting.

Neuro: agitation, dizziness, manic reactions (in patients with bipolar disorder), mild insomnia.

Interactions

Natural-Drug Products:

Natural-Natural Products:

Route/Dosage

Availability

Assessment

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Ademetionine, S-adenosylmethionine