Spectrum:
Absorption: Poorly absorbed following oral administration because of extensive first-pass hepatic metabolism, resulting in rapid conversion to albendazole sulfoxide, the active metabolite.
Distribution: Widely distributed.
Protein Binding: 70% bound to plasma proteins.
Half-Life: Albendazole sulfoxide: 812 hr.
Contraindicated in:
Use Cautiously in:
Derm: reversible alopecia
GI: ↑liver enzymes (↑ in hydatid disease), abdominal pain (hydatid disease only), nausea/vomiting (↑ in neurocysticercosis)
Hemat: AGRANULOCYTOSIS, GRANULOCYTOPENIA, PANCYTOPENIA
Neuro: headache (↑ in neurocysticercosis), ↑intracranial pressure (↑ in neurocysticercosis), dizziness/vertigo, meningeal signs (in neurocysticercosis only)
Misc: fever (hydatid disease only)
Drug-drug:
Hydatid Disease
Neurocysticercosis
Lab Test Considerations: