section name header

Pronunciation

FLEK-a-nide

Classifications

Therapeutic Classification: antiarrhythmics (class IC)

Indications

REMS


Unlabeled Use:
  • Single dose treatment of atrial fibrillation.

Action

  • Slows conduction in cardiac tissue by altering transport of ions across cell membranes.
Therapeutic effects:
  • Suppression of arrhythmias.

Pharmacokinetics

Absorption: Well absorbed from the GI tract following oral administration.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Mostly metabolized by liver; 30% excreted unchanged by kidneys.

Half-Life: 11–14 hr.

Time/Action Profile

(antiarrhythmic effects)

ROUTEONSETPEAKDURATION
POdaysdays–weeks12 hr





Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: ARRHYTHMIAS, HF, chest pain

EENT: blurred vision, visual disturbances

GI: anorexia, constipation, drug-induced hepatitis, nausea, stomach pain, vomiting

Derm: rash

Neuro: dizziness, anxiety, depression, fatigue, headache, tremor

Interactions

Drug-drug:

Route/Dosage

Ventricular Tachycardia

Renal Impairment

Paroxysmal Supraventricular Tachycardia/Paroxysmal Atrial Fibrillation/Flutter

Atrial Fibrillation Conversion (unlabeled)

Availability

(Generic available)

Assessment

Lab Test Considerations:

Toxicity and Overdose:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

Canadian Brand Names

Tambocor