Therapeutic Classification: antidepressants
Pharmacologic Classification: selective serotonin and norepinephrine reuptake inhibitors-SSNRIs
Absorption: Well absorbed (92%) following oral administration.
Distribution: Widely distributed.
Half-Life: 12 hr.
Contraindicated in:
Use Cautiously in:
CV: hypertension, hypotension, palpitations, tachycardia
Derm: hot flushes, hyperhidrosis, rash
EENT: mydriasis
Endo: SIADH
F and E: hyponatremia
GI: nausea, ↓appetite, constipation, vomiting
GU: ↓libido, delayed/absent orgasm, ejaculatory delay/failure, erectile dysfunction, testicular pain, urinary hesitation/retention
Hemat: BLEEDING
Neuro: activation of mania/hypomania, SUICIDAL THOUGHTS/BEHAVIORS
Misc: SEROTONIN SYNDROME
Drug-drug:
Drug-Natural Products:
Renal Impairment
Lab Test Considerations:
Do not confuse Fetzima with Farxiga.