section name header

Pronunciation

proe-METH-a-zeen

Classifications

Therapeutic Classification: antiemetics, antihistamines, sedative/hypnotics

Pharmacologic Classification: phenothiazines

Indications

BEERS REMS, High Alert


Action

  • Blocks the effects of histamine.
  • Has inhibitory effect on the chemoreceptor trigger zone in the medulla, resulting in antiemetic properties.
  • Alters the effects of dopamine in the CNS.
  • Possesses significant anticholinergic activity.
  • Produces CNS depression by indirectly decreased stimulation of the CNS reticular system.
Therapeutic effects:
  • Relief of symptoms of histamine excess usually seen in allergic conditions.
  • Diminished nausea or vomiting.
  • Sedation.

Pharmacokinetics

Absorption: Well absorbed after oral (88%) and IM administration; rectal administration may be less reliable. IV administration results in complete bioavailability.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Metabolized by the liver.

Half-Life: 9–16 hr.

Time/Action Profile

(noted as antihistaminic effects; sedative effects last 2–8 hr)

ROUTEONSETPEAKDURATION
PO, IM20 minunknown4–12 hr
Rectal20 minunknown4–12 hr
IV3–5 minunknown4–12 hr





Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: bradycardia, hypertension, hypotension, tachycardia

Derm: photosensitivity, rash, severe tissue necrosis upon infiltration at IV site

EENT: blurred vision, diplopia, tinnitus

GI: constipation, dry mouth, hepatitis

Hemat: blood dyscrasias

Neuro: confusion, disorientation, sedation, dizziness, extrapyramidal reactions, fatigue, insomnia, nervousness, NEUROLEPTIC MALIGNANT SYNDROME

Interactions

Drug-drug:

Route/Dosage

Antihistamine

Antivertigo (Motion Sickness)

Sedation

Nausea/Vomiting

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

IV Administration:

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Phenergan, Promethegan