section name header

Pronunciation

bi-val-i-ROO-din

Classifications

Therapeutic Classification: anticoagulants

Pharmacologic Classification: thrombin inhibitors

Indications

High Alert


Action

  • Specifically and reversibly inhibits thrombin by binding to its receptor sites. Inhibition of thrombin prevents activation of factors V, VIII, and XII; the conversion of fibrinogen to fibrin; platelet adhesion and aggregation.
Therapeutic effects:
  • Decreased acute ischemic complications in patients with unstable angina (death, MI, or the urgent need for revascularization procedures).

Pharmacokinetics

Absorption: IV administration results in complete bioavailability.

Distribution: Unknown.

Metabolism/Excretion: Cleared from plasma by a combination of renal mechanisms and proteolytic breakdown.

Half-Life: 25 min ( in renal impairment).

Time/Action Profile

(anticoagulant effect)

ROUTEONSETPEAKDURATION
IVimmediateunknown1–2 hr





Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Interactions

Drug-drug:

Drug-Natural Products:

Route/Dosage

Renal Impairment

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

IV Administration:

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Angiomax