Therapeutic Classification: antigout agents
Pharmacologic Classification: xanthine oxidase inhibitors
REMS
Absorption: Well absorbed (49%) following oral administration.
Distribution: Widely distributed to tissues.
Protein Binding: 99.2%.
Half-Life: 58 hr.
(plasma concentrations)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO | rapid | 11.5 hr* | 24 hr |
*Maximum lowering of uric acid may take 2 wk.
Contraindicated in:
Use Cautiously in:
Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS
GI: ↑liver enzymes, nausea
MS: arthralgia, gout flare
Drug-drug:
Renal Impairment
Lab Test Considerations: