Therapeutic Classification: antifibromyalgia agents
Pharmacologic Classification: selective norepinephrine reuptake inhibitors
Absorption: 8590% absorbed following oral administration.
Distribution: Unknown.
Half-Life: D: isomer 810 hr; L: isomer 46 hr.
Contraindicated in:
Use Cautiously in:
CV: hypertension, tachycardia
Derm: ↑sweating, hot flush
Endo: SIADH
F and E: hyponatremia
GI: ↑liver enzymes, constipation, dry mouth, nausea, PANCREATITIS, vomiting
GU: ↓libido, delayed/absent orgasm, ejaculatory delay/failure, erectile dysfunction
Hemat: BLEEDING
Neuro: dizziness, headache, insomnia, NEUROLEPTIC MALIGNANT SYNDROME, SUICIDAL THOUGHTS
Misc: SEROTONIN SYNDROME
Drug-drug:
Drug-Natural Products:
Renal Impairment
Lab Test Considerations: